The original C57BL/6 was generat


The original C57BL/6 was generated in 1921 by Dr. C. C. Little. Add to cart.

Add to cart. All animals were 612 weeks old; the exact age and weight of the animals used can be found in online suppl.

To Olac in 1983 (now Envigo). 607 Ideal For. 39. These data are consistent with previous observations that showed P. yoelii infection of C57BL/6 mice from Taconic and Jackson Laboratories had lower parasitemia than C57BL/6 mice from Charles River, National Cancer Institute, and Envigo (formally Harlan; Villarino et al., 2016). Kupffer cells were identified as F4/80 hi CD11b lo . ZERO BIAS - scores, article reviews, protocol conditions and more

C57BL/6 mice were with injected 210 6 MC38 cells and treated on days 7, 10, and 13 with 400 g of isotype control or single agent, or 200 g of each agent for the combination therapy. C57BL/6 substrains. C57BL/6J is the parental substrain; J is the laboratory code for The Jackson Laboratory. Therefore, there is no source of C57BL/6 mice; there is always a longer designation for each substrain indicating the institute or laboratory that maintains the different colonies. 4-week-old BALB/c and C57BL/6 mice were purchased from Charles River. Mortality also includes mice that were sacrificed because they had lost more than 25% of body weight. Weight loss and survival of infected mice was followed over a period of 14 days. Introducing the C57BL/6 germ-free mouse, the latest addition to the Charles River research animal models portfolio. 309 citations have been found for this product.

Add to cart. Serum samples were collected from colon carcinoma (Balb/c) and melanoma (C57BL/6) bearing mice as well as tumor-free animals.

Show Donor Details . Infested immunocompetent animals developed diffuse alopecia by day 112, and both BALB/c and C57BL/6 mice had significantly increased IgE levels. C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception Mol Pain. 3 Stanford University, Department of Comparative Medicine, Stanford, California, USA. Anti-PD-1 vs control p = 0.0013; anti-PD-1 and anti-CTLA-4 vs control Cohorts of specific pathogen free (SPF, according to FELASAs exclusion list 78, 79) male and female C57BL/6 mice were delivered from Charles River (strain C57BL/6 J), Germany, or Janvier labs (strain C57BL/6Rj), France, (Table (Table1).

In Cell Reports on 22 March 2022 by Hauser, B. M., Sangesland, M., et al.. A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis. La souris C57BL/6 a t dveloppe par C.C Little en 1921. The

and Use Committee. General Purpose - Atochina, E.N. Behavior was assessed in open field chambers using both automated photobeam interruptions and behavioral observations. Be the first to review this product.

S3 Fig: CD4 Depletion Increases and CD8 Depletion Decreases Antitumor Activity of Treatment Antibodies.A. Light Schedules and Housing .

Female C57BL/6 mice were received from Charles River Kingston (Stone Ridge, NY). C57BL/6NCrl . Figure Legend Snippet: Ti doping ameliorated the pro-fibrogenic effects of repetitively dosed fumed silica C57BL/6 (n=6) mice were exposed to either a single dose of 21 mg/kg or 3 doses of 7 mg/kg non-doped or 7% Ti-doped fumed silica, one week apart.

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Research Models & Services Catalog. Eight week-old virgin C57BL/6 J female mice were obtained from the Charles River laboratory. Request PDF | Abstract 6025: Baseline cytokine profiling in nave and tumor-bearing Balb/c and C57BL/6 Charles River mice | Background: Syngeneic studies are still the backbone of oncology research.

Show Donor Details . 2012530 Behavior was assessed in open field chambers using both automated photobeam interruptions and behavioral observations. Genetically modified C57BL/6 mice appear repeatedly in many studies describing new animal models for human diseases (i.e. on CD-1 Mice Versus C57BL/6 Mice.

All of the substrains were bred for one generation at the University of Lot Number: Login to view. Female C57BL/6 mice 68 weeks old were purchased from Taconic Biosciences (Hudson, NY) and Charles River Laboratories (Wilmington, MD). Charles River Laboratories timed pregnant c57bl 6j mouse embryos Timed Pregnant C57bl 6j Mouse Embryos, supplied by Charles River Laboratories, used in various techniques. C57BL/6J vs. C57BL/6N. In 1951, C57BL/6J mice were sent to the National Institutes of Health (NIH) where a colony was established and was called C57BL/6N. The responsible mutation appears to have occurred at NIH (*), subsequent to the separation of the ByJ lineage in 1961 and prior to the transfer of mice to Charles River in 1974.

CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland.

1; for all online suppl. Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting.

Manufacturer Charles River. Mice were fed a diet containing 6% fat (LabDiet 5K52 formulation). Charles River Acquires Explora BioLabs. Charles River Cortex Investigational Analysis Software (11) Contract Testing Services (4) Endosafe LAL Cartridge Technology (24) Endosafe nexgen-MCS (16) Endosafe nexgen-PTS (26) Endosafe Nexus Robotic System (14) EndoScan-V Endotoxin Measuring Software (10) LAL Reagents and Accessories (24) Low Endotoxin Recovery (12) C57BL/6 Dendritic Cells 5-10M. NCrl (C57BL/6NCrl) is the line maintained by Charles River Laboratories, and it is estimated that it was received at approximately generation F 95. Add to cart. The rest of the substrains were derived from the original line at different time points as indicated on the graph. Litter size varies among strains (Table 1), ranging from about two to three pups/litter in some poorly breeding 129

injection of 5 x 10 7 EcN or L-Arg bacteria, or with PBS. In 2005, JAX received C57BL/6N cryopreserved embryos derived from a father-daughter backcross of a 1984 freeze at approximately F126 (now called C57BL/6NJ). RESEARCH MODELS C57BL/6 Mice Nomenclature: C57BL/6NCrl Strain Origin Developed by C.C. Little in 1921 from a mating of Miss Abbie Lathrops stock that also gave rise to strains C57BR and C57L.

C57BL/6 Bone Marrow Cells 5-10M. C57BL/6 mice from Taconic exhibit reduced parasitemia compared to mice from Charles River. Show Donor Details .

Jan-Dec 2019;15:1744806918825046. doi: 10.1177/1744806918825046. They are more sensitive to noise and odours and are more likely to bite than the more docile laboratory strains such as BALB/c.. Group-housed C57BL/6 mice (and other strains) display barbering behaviour, in which the dominant mouse in a cage selectively removes hair from its subordinate cage mates. They are also susceptible to Abstract: The C57BL/6 mouse is the most well-known inbred mouse strain, and has been widely used as a genetic background for congenic and mutant mice. C57BL/6J, DBA/2J, DBA/2NHsd and (C57BL/6JDBA/2J) F1 (labeled B6D2F1 in the figure) mice were infected intra-nasally with 210 3 FFU PR8 virus. ( A ) Flow cytometric analysis of hepatic leukocytes at 48 h after APAP challenge. C57BL/6 Mouse C57BL/6 Mouse by Charles River Manufacturer Charles River Be the first to review this product Developed by C.C. Little research has been conducted to examine the influence of various methods of providing nest materials-such as dispersing them, providing them as single units, or clustering them-on the behavior and welfare of group-housed mice. C57BL/6 Bone Marrow Cells 5-10M quantity. 1c).

Jan-Dec 2019;15:1744806918825046. doi: 10.1177/1744806918825046.

49 strains (Schmidt, Lolley, & Racz, 1973) and age-related deafness in C57BL/6 strains 50 (Johnson, Erway, Cook, Willott, & Zheng, 1997). Strains 6 and 10 separated about 1937.

A number of C57BL/6 C3H/HeNCrlCrlj were purchased from Charles River Laboratories Japan, Inc. (Yokohama, Japan). On day 21, BAL fluid was collected to determine (A) IL-1, (B) LIX, and (C) TGF-1 levels. C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception Mol Pain. C57BL/6 mouse cells are isolated from C57BL/6 mice purchased from Charles River. Phase I, II, and III type 2 diabetes, obesity research, wound healing Growth chart data should be used as a guideline only. Values represent mean and one standard deviation. Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allodynia) instead of the insensate neuropathy (mechanical insensitivity) that normally develops in this strain. Percent parasitemia was determined on the indicated days. Origin: C57BL/6JOlaHsd mice originate from the Jackson Laboratory, Bar Harbor, Maine. Genealogy of the C57BL/6 mouse substrains. Female C57BL/6NCrl mice (age, 12 to 14-wk) were obtained from Charles River (Wilmington, MA) and were maintained in facilities in which sentinel mice tested this volume is within the range of safe amounts to collect weekly from female C57BL/6 mice. Before the experiment, five mice per cage were maintained in a room with controlled temperature and humidity under a 07:0019:00 h light cycle with free access to food and water. C57BL/6 Dendritic Cells 5-10M. They were imported to the US in 1926 and to Charles River in 1959. All work was conducted at Charles River's AAALAC-accredited Wilmington, MA, facility and was approved by Charles River's IACUC (P08042010). C57BL/6 mice were injected intraperitoneally with APAP at 400 mg/kg (body weight) to induce acute liver injury. Size: 05-10M cells/vial. Bioz Stars score: 86/100, based on 1 PubMed citations. C57BL/6 Bone Marrow Cells 5-10M. 8 Program in Immunology, Memorial Sloan Kettering Cancer Center, New York, New York. C57BL/6J mice present a deletion (~17 Kbp) in C57BL/6 C57 black 6C57black6; : B6 . 1023-1063spf10803002015 Bioz Stars score: 86/100, based on 1 PubMed citations. Strains 6 and 10 separated about 1937.

Male C57BL/6J mice aged 6 weeks (Japan Charles River, Tokyo, Japan) were used. C57BL/6 Dendritic Cells 5-10M.

C57BL/6 (B6) is the most widely used inbred mouse strain, but its use in epilepsy research is compromised by low sensitivity to various convulsants, including pilocarpine.